目的：对FS-LASIK术矫正近视合并高度散光早期前房深度、前后表面曲率及散光的变化进行观察并与较低散光组对比。

方法：选取2016-01/2019-05在我院行飞秒制瓣LASIK手术治疗复合性近视散光且3mo内有完整随访记录的患者进行回顾性分析，根据手术设计的散光大小分为两组：A组71例106眼，散光-2.00～-5.00D，等效球镜-6.15±1.74D； B组63例106眼，散光-0.25～-1.00D，等效球镜-6.67±1.04D； 常规围手术期检查。所有病例按照飞秒制瓣LASIK术式常规操作流程完成手术。比较两组术后前房深度、前后表面曲率及散光。

结果：术前和术后1wk，1、3mo两组后表面曲率、散光及前房深度变化无差异(P>0.05)。术后1wk，1、3mo两组前表面曲率无差异(P>0.05)。A组前表面散光术后1wk与1、3mo均有差异(P<0.05)，1mo与3mo无差异(P>0.05)。B组前表面散光术后1wk～3mo无差异(P>0.05)。

结论：近视合并高度散光行FS-LAISK术后后表面曲率、散光及前房深度无明显变化，前表面曲率在术后1wk～3mo较稳定，但前表面散光数值在术后1wk～3mo时略呈现增加趋势，在术后1～3mo较稳定。

METHODS: One hundred and thirty-four cases(212 eyes)undergone femtosecond laser-assisted LASIK in our hospital were included. They were selected and divided into two groups based on astigmatism. The group A:astigmatism -2.00D to -5.00D, spherical equivalent -6.15±1.74D. The group B:astigmatism -0.25D to -1.00D, spherical equivalent-6.67±1.04D. Patients were examined 1wk, 1mo and 3mo. Visual acuity, intraocular pressure, refraction, corneal curvature and anterior chamber depth were recorded. The changes of corneal curvature and astigmatism and anterior chamber depth were compared. Spearman correlation analysis and independent t-test were used for statistical analysis.

RESULTS: No statistically significant difference was found in posterior corneal curvature and astigmatism and anterior chamber depth of the groups A and B at preoperative, postoperative 1wk, 1mo and 3mo(P>0.05). No statistically significant difference was found in anterior corneal curvature of the groups A and B at postoperation 1wk, 1mo and 3mo(P>0.05). One week postoperative, the anterior corneal astigmatism of the group A was statistically significant from that of 1mo and 3mo postoperative(P<0.05), there were no significant differences at 1mo, 3mo after operation(P>0.05). No statistically significant difference was found in anterior corneal astigmatism of the group Bat postoperation 1wk, 1mo and 3mo(P>0.05).

CONCLUSION: When correct high astigmatism, no significant changes of posterior corneal curvature and anterior chamber depth was found after femtosecond laser-assisted LASIK for correct myopic astigmatism. The anterior corneal curvature was stable from 1wk to 3mo.The astigmatism was stable from 1mo to 3mo.