目的：比较马来、中国、印度和尼日利亚4个不同人群的无创性泪膜破裂时间(NIBUT)、泪膜破裂时间(TBUT)、基础泪液分泌量(BTS)和眨眼频率。

方法：共纳入120例(男性61例，女性59例)年龄20～39岁健康受试者，其中30例马来人，30例中国人，31例印度人，29例尼日利亚人。根据McMonnies调查问卷和临床检查，挑选了健康受试者。选取受试者右眼评估NIBUT、TBUT、BTS，及眨眼频率。

结果：四组人群中NIBUT、TBUT、BTS，及眨眼频率具有显著差异(P=0.018，P=0.001，P=0.011，P=0.004)。不同民族人群性别间NIBUT、TBUT、BTS和眨眼频率差异无统计学意义。相较于其他三组，印度人NIBUT(10±6s)，TBUT(7±5s)和BTS(20±20 mm)中位数较高，中国人NIBUT(7.5±4s)和TBUT(4±2s)中位数较低，马来人BTS为9.5±16mm。眨眼频率与NIBUT、TBUT、BTS间无显著相关(r= -0.119，P=0.195)，(r= -0.086， P=0.352)，(r=-0.123，P=0.180)。

结论：研究体现了四个不同国家人群间泪膜测量值的差异性。

METHODS: Totally 120 healthy(61 males and 59 females)subjects(without dry eye symptoms and ocular surface disorder)with the age 20 to 39 years were recruited; 30 were Malays, 30 were Chinese, 31 were Indians and 29 were Nigerians. Based on McMonnies questionnaire and clinical examination, normal subjects were selected. NIBUT, TBUT, BTS were assessed in only one eye(right)of each subject and blink rate was also assessed.

RESULTS: There was significant difference in the NIBUT, TBUT, BTS and blink rate among 4 different ethnic groups(P=0.018),(P=0.001),(P=0.011), and(P=0.004)respectively. No statistically significant difference of NIBUT, TBUT, BTS and blink rate was found between the genders among different ethnic groups. Indian had higher median for NIBUT(10±6s), TBUT(7±5s)and BTS(20±20 mm)than others races. Chinese had lower median for NIBUT(7.5±4s)and TBUT(4±2s)while Malay had low BTS(9.5±16 mm)among the groups. There was no significant correlation of blink rate with NIBUT, TBUT and BTS(r= -0.119, P=0.195),(r=-0.086, P=0.352),(r= -0.123, P=0.180)respectively.

CONCLUSION: This study showed the variability in tear-film measurements values in four ethnic groups.