[关键词]
[摘要]
miRNA-15a(miR-15a)是位于13q14基因上的非编码RNA小分子，随着研究的深入，其对全身各组织器官及细胞的生长、凋亡等调控作用越发被重视，成为现今研究较多的miRNA。本文主要针对miR-15a的作用机制及在眼科疾病中的研究现况进行阐述，为进一步研究眼科疾病及治疗提供可借鉴的参考依据。
[Key word]
[Abstract]
miRNA-15a(miR-15a)is a non-coding small molecule RNA located on 13q14 gene. It affects the growth, development, differentiation and apoptosis of all organs and cells of the whole body. As the study progressively deepened, it was found that the role of miR-15a in different tissues and cells was not entirely consistent. Sometimes it plays a role in suppressing cancer, and sometimes it promotes cancer. The signal pathways it affects are complex and diverse. With the deepening of biological research into cell signaling pathways, miRNA-15a has become a miRNA more extensively studied. But in the ophthalmology, the corresponding research is not much. In this article, we mainly focus on the mechanism of miR-15a and its current research situation in ophthalmic diseases, so as to provide a reference for further study and their treatment.
[中图分类号]
[基金项目]
国家自然科学基金(No.81470633)
