目的：探讨盐酸氮卓斯汀联合普拉洛芬治疗儿童变态反应性结膜炎的疗效。

方法：选择我院2016-05/2018-06接诊的变态反应性结膜炎患儿80例160眼，根据治疗方法不同分为两组，对照组40例80眼给予普拉洛芬滴眼液治疗，观察组40例80眼在对照组基础上联合盐酸氮卓斯汀滴眼液进行辅助治疗。两组患儿均连续治疗1wk。比较两组患儿临床疗效、临床症状、泪膜稳定性、炎症因子的变化情况及不良反应。

结果：治疗1wk后观察组临床总有效率为95.0%，高于对照组的85.0%(P=0.035)。观察组患儿眼痒、流泪、异物感、畏光的评分均低于对照组\〖(1.13±0.36)vs(2.28±0.41)分，(1.05±0.33)vs(2.14±0.49)分，(1.17±0.46)vs(2.28±0.59)分，(1.29±0.37)vs(1.84±0.55)分\〗(P<0.05)； 观察组患儿的泪膜破裂时间(BUT)明显高于对照组，角膜荧光素染色试验(FL)明显低于对照组\〖(11.96±1.14)vs(5.85±0.92)s，(2.85±0.33)vs(6.21±0.68)分\〗(P<0.05)； 观察组患儿泪液中组胺(HA)、嗜酸性细胞阳离子蛋白(ECP)和免疫球蛋白E(IgE)水平均低于对照组\〖(31.62±4.51)vs(65.03±6.48)μg/L，(2.20±0.28)vs(7.26±0.72)μg/L，(0.06±0.01)vs(0.18±0.04)mg/L\〗(P<0.05)； 两组患儿治疗期间的不良反应总发生率无差异(χ²=1.897，P=0.168)。

结论：盐酸氮卓斯汀联合普拉洛芬治疗儿童变态反应性结膜炎的效果明显，能有效改善炎症因子指标水平，促进泪膜稳定性的恢复，安全性好。

METHODS: Totally 80 children with allergic conjunctivitis who were admitted to our hospital from May 2016 to June 2018, they were randomly divided into the control group and the observation group, 40 cases in each group. The control group was given pranoprofen eye drops, on the basis of the control group, the observation group was combined with azelastine hydrochloride eye drops for adjuvant treatment. The two groups children were treated continuously for 1wk. The clinical efficacy, the changes of the clinical symptoms, tear film stability, inflammatory factors and adverse reactions were compared between the two groups.

RESULTS: After 1wk of treatment, the clinical efficacy of the observation group was 95.0%, higher than that of the control group, 85.0%(P=0.035); the itching, tearing, foreign body sensation and photophobia scores in the observation group were lower than that of the control group \〖(1.13±0.36)vs (2.28±0.41)scores,(1.05±0.33)vs (2.14±0.49)scores,(1.17±0.46)vs (2.28±0.59)scores(1.29±0.37)vs (1.84±0.55)scores\〗(P<0.05); the tear film rupture time(BUT)in the observation group was significantly higher than that of the control group, and the corneal fluorescein staining test(FL)was significantly lower than that of the control group \〖(11.96±1.14)vs (5.85±0.92)s,(2.85±0.33)vs (6.21±0.68)scores\〗(P<0.05); the tears histamine(HA), eosinophilic cationic protein(ECP)and immunoglobulin E(IgE)in the observation group were lower than that of the control group \〖(31.62±4.51)vs (65.03±6.48)μg/L,(2.20±0.28)vs (7.26±0.72)μg/L,(0.06±0.01)vs (0.18±0.04)mg/L\〗(P<0.05); there was no significant difference in the overall incidence of adverse reactions between the two groups during treatment(χχ²=1.897, P=0.168).

CONCLUSION: The clinical efficacy of azelastine hydrochloride combined with pranoprofen in the treatment of allergic conjunctivitis in children is significant, which can effectively improve the level of inflammatory factors, promote the tear film stability recovery, and have good safety, the clinical value is high.