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[摘要]
目的：通过光学相干断层扫描血管成像(OCTA)技术观察湿性年龄相关性黄斑变性(wARMD)经抗血管内皮生长因子(VEGF)治疗后的脉络膜新生血管(CNV)选定病灶面积(CSA)和血流面积(CFA)变化情况，探讨OCTA在该类疾病治疗效果评估方面的优势。
方法：回顾性分析2018-02/2019-07在我院眼科确诊为wARMD并且在我院接受首次抗VEGF药物治疗及后续治疗的患者22例27眼纳入分析研究。所有患者均按3+prn方案给予抗VEGF药物治疗。对比观察患眼治疗前后最佳矫正视力(BCVA)，黄斑中心凹视网膜厚度(CMT)、CSA、CFA变化。采用Pearson相关分析法，分析BCVA(LogMAR)与CMT、CSA、CFA的相关性。
结果：wARMD患眼治疗后3mo BCVA(0.512±0.367)、CMT(223.271±17.795μm)、CSA(0.085±0.013mm2)、CFA(0.015±0.008mm2)较治疗前均显著改善(P<0.05)； 治疗后3mo BCVA与治疗前及治疗后3mo CMT、CSA、CFA均呈正相关(P<0.05)。
结论：OCTA能够清晰显示并量化wARMD抗VEGF药物治疗前后CSA和CFA变化，为wARMD治疗效果评估提供参考。
[Key word]
[Abstract]
AIM: To observe the changes of selected area of choroidal neovascularization(CSA)and flow area of choroidal neovascularization(CFA)before and after the treatment of anti-vascular endothelial growth factor(VEGF)by optical coherence tomography angiography(OCTA), and to explore the advantages of OCTA in the treatment and prognosis of wet age-related macular degeneration(wAMD).
METHODS: A retrospective analysis was performed on 22 patients(27 eyes)who were diagnosed with wARMD and received the first anti-VEGF drug treatment and subsequent treatment in the Department of Ophthalmology of our hospital from 2018-02 to 2019-07. All patients were treated with anti-VEGF drugs according to the 3+prn regimen. The best corrected visual acuity(BCVA),macular foveal retinal thickness(CMT), CSA, and CFA were compared before and after treatment. We analyzed the correlation between BCVA(LogMAR)and CMT, CSA, CFA by Pearson correlation analysis.
RESULTS: After 3mo of the treatment, the mean LogMAR BCVA(0.512±0.367), CMT(223.271±17.795μm),CSA(0.085±0.113mm2)and CFA(0.015±0.008mm2)were significantly lower than those before treatment(P<0.05). The results of correlation analysis showed that the post- BCVA was positively correlated with pre-CMT, post-CMT, pre-CSA, post-CSA, pre-CFA and post-CFA(P<0.05).
CONCLUSION: OCTA can directly display and quantify the changes of CSA and CFA before and after anti-VEGF treatment of wAMD, and provide a reference for the evaluation of wAMD treatment effects.
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