目的：A/B超联合造影自发荧光观察YAG激光治疗生理性玻璃体混浊的临床效果。

方法：筛选2018-08/2019-01在汉口爱尔眼科医院诊断为生理性玻璃体混浊患者30例30眼，术前A/B超定位玻璃体混浊位置，距离晶状体2～3mm、视网膜3～4mm范围外为安全距离。检查患者术前最佳矫正视力、非接触眼压、扫描激光眼底照相、A/B超、造影自发荧光，由同一位操作熟练的医生应用YAG激光消融机对生理性玻璃体混浊进行激光消融治疗。激光治疗后随访1d，1wk，1mo，术后检查最佳矫正视力、非接触眼压、扫描激光眼底照相、造影自发荧光检查，采用Image-J软件测量治疗前后玻璃体混浊大小。

结果：治疗前，治疗后1d，1wk，1mo最佳矫正视力、眼压均无差异(P>0.05)。30眼中，28眼一次激光消融治疗，2眼2次激光消融治疗，平均治疗次数1.06次。治疗后造影自发荧光显示玻璃体混浊明显减小或消失，前后对比有差异(P<0.01)。术中及术后均无并发症发生。

结论：A/B超联合造影自发荧光证实YAG激光治疗生理性玻璃体混浊安全有效。

METHODS: Screening of 30 patients(30 eyes)with physiological vitreous floaters from August 2018 to January 2019 in Hankou Aier Eye Hospital, we used A/B ultrasound to measure the distance from the wall of the ball and the back surface of the lens before operations. Check the patient's best corrected visual acuity, non-contact intraocular pressure, scanning laser fundus photography, A/B ultrasound and autofluorescence(AF)of angiography before treatment, laser ablation was performed by the same skilled doctor using ELLEX YAG laser ablation machine. After treatment, the patients were followed up at the point of 1d, 1wk, and 1mo. The same examination was performed after operation. The Image-J software was used to measure the vitreous opacity in the autofluorescence of angiography pictures before and after treatment.

RESULTS:There was no significant difference in the best corrected visual acuity and non-contact intraocular pressure before and after treatment(P>0.05). Of the 30 eyes, 28 eyes underwent laser ablation treatment once, and 2 eyes underwent laser ablation treatment twice. The average number of treatments was 1.06. After treatment, the autofluorescence of angiography showed that the vitreous opacity was obviously reduced or disappeared, and the difference was statistically significant before and after treatment(P<0.01). No complications occurred during or after surgery.

CONCLUSION: A/B ultrasound combined with autofluorescence confirmed that Nd:YAG laser is safe and effective in the treatment of physiological vitreous floaters.