目的：分析房水中白细胞介素-6(IL-6)和单核细胞趋化因子-1(MCP-1)浓度与视网膜静脉阻塞(RVO)合并黄斑水肿的相关性。

方法：选取2017-11/2019-11在内蒙古自治区人民医院确诊为RVO并接受玻璃体腔内注射雷珠单抗(IVR)治疗的患者40例40眼为治疗组，选取同期行白内障手术的单纯年龄相关性白内障患者20例20眼为对照组。采集两组患者房水，并检测房水中MCP-1和IL-6浓度。治疗组患者分别于首次IVR术前和术后1mo进行最佳矫正视力(BCVA)和黄斑区中心凹厚度(CMT)检测，分析术前房水中IL-6和MCP-1浓度及CMT的相关性。

结果：术前，治疗组患者房水中IL-6和MCP-1浓度(49.84±16.16、547.75±108.45pg/mL)明显高于对照组(10.71±7.26、235.65±34.45pg/mL，均P<0.001)，且治疗组患者房水中IL-6和MCP-1浓度与CMT呈正相关(r=0.646、0.912，均P<0.001)，IL-6与MCP-1浓度呈正相关(r=0.902，P<0.001)。首次IVR术后1mo，与术前相比，治疗组患者房水中IL-6、MCP-1浓度(20.08±11.56、228.35±70.69pg/mL)显著下降，BCVA和CMT明显改善(均P<0.001)。

结论：房水中IL-6和MCP-1浓度与RVO病变进程相关，玻璃体腔内注射雷珠单抗能够降低房水中IL-6和MCP-1的表达，降低CMT，减轻黄斑区水肿，改善视力。

METHODS: Forty patients(40 eyes)diagnosed with RVO macular edema were selected as the treatment group, twenty patients(20 eyes)underwent cataract surgery were selected as the control group, anterior aqueous humor was collected before surgery in the treatment group and control group. Using the cytometric bead array methods detection the concentration of MCP-1 and IL-6. Comparison and analysis the concentration of MCP-1 and IL-6 before the operation treatment group and control group, comparison and analysis the concentration of MCP-1 and IL-6, BCVA, CMT before and after the operation in the treatment group.

RESULTS: The concentration of MCP-1(49.84±16.16、547.75±108.45pg/mL)and IL-6 in the treatment group was higher than the control group(10.71±7.26、235.65±34.45pg/mL,all P<0.001)before the operation. There was a positive correlation between the concentration of MCP-1, IL-6 and CMT before the operation in the treatment group(r=0.646, 0.912, all P<0.001). The concentration of IL-6 was significantly correlated with MCP-1(r=0.902, P<0.001). The treatment group underwent the intravitreal ranibizumab injection was injected into the glass body cavity, the concentration of IL-6, MCP-1(20.08±11.56、228.35±70.69pg/mL)was lower than before. BCVA was improved significantly compared with before operation, CMT decreased after surgery compared to before surgery(P<0.001).

CONCLUSION: There was a positive correlation between the concentration of MCP-1, IL-6 and CMT, with IVR treatment of secondary macular edema to RVO, to reduce the concentration of MCP-1 and IL-6, to reduce CMT, and reduce macular edema, improved patient's vision level.