目的：分析北方汉德地区三级保健医院血脂异常与睑板腺功能(MGD)紊乱严重程度的关系。

方法：这项前瞻性观察研究为期1a，共纳入50例MGD患者。患者接受详细病史调查(包括眼表疾病指数问卷)和检查(包括眼底质量、表达能力和数字染色)。根据2011年睑板腺功能障碍与管理国际研讨会提交的指南对MGD进行分级。对所有患者进行空腹血脂测定。总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)和极低密度脂蛋白(VLDL)等参数与MGD严重程度相关。采用Chi-square检验进行统计学分析(P<0.05)。

结果：2级MGD是最常见的疾病(60%，n=30)。年龄的增加与MGD的严重程度呈显著正相关(P=0.004)。高TC(>200 mg/dL)、TG(>150 mg/dL)、LDL(>130 mg/dL)和VLDL(>22 mg/dL)水平与MGD的严重程度呈正相关(P=0.001，0.019，0.001，0.016)。

结论：监测空腹血脂水平可以帮助确定MGD的严重程度，进一步的研究可以确定血脂异常在治疗MGD中的作用。

METHODS: This prospective observational study was conducted over a period of one year including 50 consecutive patients of MGD. Patients underwent detailed history(including Ocular Surface Disease Index Questionnaire)and examination(including meibum quality, expressibility and numerical staining). MGD was graded according to the guidelines submitted by the International Workshop on Meibomian Gland Dysfunction and Management in 2011. Fasting lipid profile of all the patients was done. Various parameters of lipid profile including total cholesterol(TC), triglycerides(TG), low density lipoproteins(LDL), high density lipoproteins(HDL)and very low density lipoproteins(VLDL)were correlated with MGD severity. Chi-square test was done for statistical analysis(P<0.05).

RESULTS: Stage 2 MGD was the most common disease entity(60%, n=30). A significant positive correlation was noted between increasing age and severity of MGD(P=0.004). High TC(>200 mg/dL), TG(>150 mg/dL), LDL(>130 mg/dL)and VLDL(>22 mg/dL)levels had a significant positive correlation with the severity of MGD(P=0.001, 0.019, 0.001, 0.016 respectively).

CONCLUSION: Monitoring the fasting lipid levels may aid in establishing the severity of MGD and further studies may be conducted to establish the role of treatment of dyslipidemia in MGD.