[关键词]
[摘要]
青光眼是全球范围内导致视功能障碍的一大主要原因，是一组涉及视神经和相关结构的疾病，最终导致不可逆的失明。研究认为，诱导青光眼的发病机制主要为机械压迫学说和血管学说(微循环)。随着临床研究及诊疗的发展，后者已成为青光眼研究的重点和发展方向。青光眼患者出现视乳头、视盘、甲床皱襞毛细血管等相应部位血管密度的降低，通过深度卷积神经网络和光学相干断层扫描血管造影等技术可客观阐述其微循环相应参数的改变，并对青光眼的病程进展具有一定监测作用。本文从青光眼与微循环改变进行综述，旨在扩充临床上对于青光眼的认识，从而进一步指导临床诊治。
[Key word]
[Abstract]
Glaucoma is a major cause of visual dysfunction worldwide. It is a group of diseases involving the optic nerve and related structures. It is characterized by visual field defects and optic disc depression, which ultimately lead to irreversible blindness. Many years of research have found that the pathogenesis of induced glaucoma is mainly mechanical compression theory and vascular theory(microcirculation). In view of the current clinical research and further development of diagnosis and treatment, the latter has become the focus and development direction of modern research. Patients with glaucoma will have a decrease in blood vessel density in the corresponding parts such as the optic papilla and optic disc. Examination techniques such as deep convolutional neural network and OCT-A can objectively explain the changes in the corresponding parameters of their microcirculation and can monitor the progress of glaucoma. Therefore, this article discusses from the aspects of glaucoma and microcirculation, aiming to expand the clinical understanding of glaucoma microcirculation, so as to further guide the clinical.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81674031)
