[关键词]
[摘要]
干眼症是一种眼科常见疾病。随着泪液的非侵入性取样方法的优化，使泪液蛋白分析逐渐成为干眼症疾病诊断和疗效评价的一个最佳选择。已经用于泪液蛋白质组学研究的方法主要包括蛋白芯片技术和质谱检测技术。泪液中的蛋白质及其浓度与不同病理状况之间的关系在干眼症研究中具有重要的价值。在本文中我们回顾了该领域的最新发展、泪液蛋白质组学研究的应用以及当前存在的实际问题，以期为干眼症发生发展的机制研究和分子生物学诊断提供思路。
[Key word]
[Abstract]
Dry eye syndrome is one of the most common ophthalmology diseases. With the improvement of non-invasive tear extraction methods, tear protein analysis becomes a best choice for the diagnosis and evaluation of efficacy of dry eye. Methods that have been used for tear proteomics research include protein chip technology and mass spectrometry. The relationship between the protein in the tear fluid and its concentration and different pathological conditions has important value in the research of dry eye syndromes. This article reviews the latest developments in the field, the application of tear proteomics research and current practical issues,it will provide highlights for the understanding of molecular mechanism of dry eye syndromes and benefits for potential molecular diagnosis of dry eye syndromes in the future.
[中图分类号]
[基金项目]
国家自然科学基金青年基金项目(No.81904302); 上海市青年科技英才扬帆计划资助(No.19YF1445000); 上海市卫生健康委员会项目(No.201940130,201840174)
