目的：探讨抗VEGF联合复合式小梁切除术治疗新生血管性青光眼的临床疗效。

方法：选取2017-01/2019-06就诊于沈阳市第四人民医院并入院治疗的符合研究条件的新生血管性青光眼患者42例43眼。患者入组后行血常规、尿常规、心电图、视力、眼压、眼前节照相，根据屈光间质状态完善眼底检查。根据入院眼压情况予全身及局部联合降眼压治疗，术前抗生素滴眼。入院第3d患者术眼行抗VEGF治疗，根据患者自主选择予玻璃体腔注射雷珠单抗或康柏西普，分为雷珠单抗组和康柏西普组； 注药72h后行复合式小梁切除术(结膜下及巩膜瓣局部应用氟尿嘧啶浸润+可调节缝线+房角分离)。术后随访6mo(1d，1、2wk，1、2、3、6mo)，比较两组新生血管消退情况、视力、眼压。

结果：康柏西普眼内注射液和雷珠单抗眼内注射液均可有效消退虹膜新生血管，治疗新生血管性青光眼疗效无差别。术后1d，1、2wk，1、2、3、6mo大部分患者眼压均明显下降，部分患者视力提高。

结论：抗VEGF联合复合式小梁切除术可有效控制新生血管性青光眼眼压，部分患者可提高视力，提升患者生活质量。

METHODS: A study was performed on the related data of 42 NVG patients(43 eyes)who were admitted to Department of Ophthalmology, the Fourth People's Hospital of Shenyang from January 2017 to June 2019. Blood routine, urine routine, electrocardiogram, visual acuity, intraocular pressure, and Scheimpflug photography were taken after all patients were enrolled, and fundus examination was completed according to the state of the refractive condition. According to the intraocular pressure, lowering intraocular pressure and antibiotic eye drops were taken before surgery. On the third day of admission, the patients were treated with anti-VEGF treatment. The patients divided into the lucentis group and conbercept group according to patient choice. Compound trabeculectomy was performed 72h after injection(subconjunctiva and scleral flap were locally infiltrated with fluorouracil + adjustable suture line+goniosynechialysis). Visual acuity and intraocular pressure were recorded 1d, 1wk, 2wk, 1mo, 2mo, 3mo and 6mo after surgery. Analysis of variance for repeated measurements to compare data before and after surgery, the independent sample t-test was used to compare the differences between groups at each time point.

RESULTS: Both lucentis and conbercept could suppress iris neovascularization. There was no significant difference between two groups. The intraocular pressure significantly decreased in most patients 1d, 1wk, 2wk, 1mo, 2mo, 3mo and 6mo after surgery. Vision acuity could be improved in some patients.

CONCLUSION: Anti-VEGF and combined with compound trabeculectomy is effective in the treatment of lowering intraocular pressure for NVG. Vision acuity and the quality of life could be improved in some patients.