目的：观察配戴夜戴型角膜塑形镜不同时间对睑板腺及睑缘蠕形螨检出率的影响。

方法：病例对照研究。选取2019-06/12我院配戴夜戴型角膜塑形镜患者47例91眼，分为短期组(配戴时间<2a)及长期组(配戴时间≥2a)，同时选取性别年龄及屈光度相匹配的配戴框架镜患者为对照组。三组均行泪膜破裂时间检查、睑板腺红外拍照及结膜眼红评分，并行睫毛采样。

结果：短期组，长期组及对照组泪膜破裂时间分别为12.68±4.59、12.37±4.97、10.45±6.04s(P>0.05)。三组球结膜眼红评分分别为0.99±0.41、0.90±0.37、0.84±0.35分(P>0.05)。三组睑板腺评分均为1(0，1)(P>0.05)。三组蠕形螨检出率及检出量分别为42%，1(1，2)个； 39%，2(1，2)个； 33%，1(1，2)个，无明显差异(均P>0.05)。角膜点染的患者中，螨虫阳性5眼，螨虫阴性11眼(P>0.05)； 睑板腺评分0分的4眼，1分以上12眼(P>0.05)； 短期组6眼，长期组10眼(P>0.05)。

结论：配戴夜戴型角膜塑形镜对患者睑板腺及睑缘蠕形螨检出率、检出数量未见明显影响，睑板腺评分及蠕形螨检出率与角膜点染无明显关系。

METHODS:Case-control study. Totally 47(91 eyes)patients who wearing keratoscopy were enrolled from June 2019 to December 2019 in Hanyang Aier Eye Hospital. According to the wearing time, they were divided into short-term group(wearing time <2a)and long-term group(wearing time≥2a). Meanwhile, patients wearing frame glasses with gender, age and diopter matching with the two groups above were selected as the control group. All patients had non-invasive tear film rupture time(NI-BUT)examination, meibomial gland infrared photography, bulbar redness score(BRS), and eyelash sampling.

RESULTS: The three groups of NI-BUT were 12.68±4.59s, 12.37±4.97s, 10.45±6.04s,(P>0.05). BRS respectively were 0.99±0.41, 0.90±0.37, 0.84±0.35,(P>0.05). Meibomian gland score for all three groups: 1(0, 1)(P>0.05). In the three groups, the detection rate and quantity of demodex were 42%, 1(1, 2); 39%, 2(1, 2); 33%, 1(1, 2),(P>0.05). Among the patients with corneal staining, 5 were mite positive and 11 were mite negative(P>0.05). Meibomian gland score: 4 eyes were 0 grade, 12 eyes were 1 grade above(P>0.05). Short-term group 6 eyes, long-term group 10 eyes(P>0.05).

CONCLUSION:There was no significant effect on meibomian gland, the detection rate and quantity of demodex in patients wearing OOK lens. Whereas no significant relationship between meibomian gland score/ demodex detection rate and corneal staining.