目的：通过光学相干断层扫描血管成像(OCTA)检测非增殖期糖尿病视网膜病变(NPDR)患者黄斑区血流各项指标，分析NPDR各期黄斑区微循环的特点。

方法：采用OCTA分别对正常人、无糖尿病视网膜病变的糖尿病患者(NDR)、轻度NPDR、中度NPDR、重度NPDR患者行OCTA检查，测定黄斑3mm×3mm范围内血流密度(VD)，旁中心凹VD、中心凹VD。

结果：深层3mm×3mm VD、深层旁中心凹VD、深层中心凹VD分别在各组间比较，均有差异(均P<0.01)； 中度NPDR、重度NPDR的3mm×3mm VD、旁中心凹VD与正常组、NDR组、轻度NPDR组均有差异(P<0.05)； 重度NPDR深层中心凹VD与正常组有差异(P=0.006)。浅层3mm×3mm VD、浅层旁中心凹VD在各组间比较均有差异(均P<0.01)； 中度NPDR组的浅层3mm×3mm VD、浅层旁中心凹VD与正常组均有差异(均P<0.01)； 重度NPDR组的浅层3mm×3mm VD、浅层旁中心凹VD与正常组、NDR组、轻度NPDR组均有差异(均P<0.01)。深浅层3mm×3mm VD、深浅层旁中心凹VD、深层中线凹VD均与视力呈线性关系。

结论：通过OCTA发现，中度、重度NPDR黄斑区血流密度下降明显，深层旁中心凹血流密度更能反映糖尿病视网膜病变病情。

METHODS: Vessel density of 3mm×3mm centered on the fovea(3mm×3mm VD), parafoveal vessel density(parafoveal VD)and foveal vessel density(foveal VD)were measured by OCTA in healthy people, NDR, mild NPDR, moderate NPDR, and severe NPDR groups.

RESULTS: Deep 3mm×3mm VD, deep parafoveal VD and deep foveal VD were decreased gradually in groups. There was statistically significant difference between moderate NPDR, severe NPDR and others in deep 3mm×3mm VD and parafoveal VD(P<0.01). There was statistically significant difference between severe NPDR and control group in deep foveal VD(P=0.006). Superficial 3mm×3mm VD and superficial parafoveal VD are statistically significant in groups. There was statistically significant difference between moderate NPDR group and control group in superficial 3mm×3mm VD and parafoveal VD(P<0.01). There was statistically significant difference between severe NPDR group and others except moderate NPDR group in superficial 3mm×3mm VD, parafoveal VD(P<0.01). There was a significant correlation of deep and superficial 3mm×3mm VD,deep and superficial parafoveal VD, deep parafoveal VD with VA.

CONCLUSION: Deep vessel density decreased more significantly in moderate NPDR and severe NPDR groups and deep parafoveal vessel density might be a potential biomarker of DR.