目的：检测异常瞬目儿童的泪膜脂质层厚度(LLT)，探讨儿童异常瞬目与LLT的关系，期待发现LLT在儿童异常瞬目中的诊断价值。

方法：前瞻性对比研究。选取2016-11/2017-02在我院眼科门诊主诉“频繁眨眼”为首诊原因的儿童患者46例为异常瞬目组，选取同期以非异常瞬目为主诉的儿童患者46例为对照组。分别对两组患者进行病史采集、裂隙灯检查、屈光检查、泪液分泌试验(SⅠt)、泪膜破裂时间(BUT)检查以及用Lipiview眼表面光干涉仪测量LLT及不完全眨眼(PB)的次数并进行比较。

结果：异常瞬目组的LLT为72.17(22.13，91.00)nm，低于对照组81.97(30.25，95.27)nm(P=0.028)； 异常瞬目组双眼平均等效球镜度数(-0.98±3.09D)、SⅠt(11.39±2.46mm/5min)较对照组(-0.24±3.06D、11.74±2.10mm/5min)无差异(P>0.05)。异常瞬目组双眼平均PB(0.58±0.28)、BUT均值(18.27±5.51s)较对照组(0.43±0.17、21.01±6.14s)有差异(P<0.05)。

结论：儿童异常瞬目与多种因素相关，LLT下降，可能是儿童异常瞬目的重要因素。

METHODS: Prospective comparative study. Selecting 46 cases of children with "frequent blink" as the first reason in our ophthalmic outpatient clinic in 2016-11/2017-02 as abnormal blink group. In the same period, 46 children with non-anomalous blink were selected as control group. The history collection, slit lamp examination, refractive examination, Schirmer I test(SⅠt), tear film break-up time(BUT), and the number of times of LLT and incomplete blink(PB)were measured and compared surface light interferometer were compared.

RESULTS: The LLT of the abnormal blink group was 72.17(22.13, 91.00)nm, which was lower than that of the control group 81.97(30.25,95.27)nm,(U=674.5, P=0.028); The mean equivalent spherical degrees(-0.98±3.09D)and SⅠt(11.39±2.46mm/5min)in the abnormal blink group were not different from those in the control group(-0.24±3.06D, 11.74±2.10mm/5min)(P>0.05). Mean PB(0.58±0.28)and mean BUT in the eyes of blink group There was a difference(18.27±5.51s)from the control group(0.43±0.17, 21.01±6.14s)(P<0.05).

CONCLUSION: Children's abnormal blinks are associated with many factors, and the LLT decline may be an important factor in children's abnormal blink.