[关键词]
[摘要]
赖氨酰氧化酶(LOX)是细胞外具有铜结合部位的氨基氧化酶，大量研究已经证实LOX可能参与许多疾病的病理发生过程。目前LOX导致疾病发展的常见变异的潜在机制仍然未知，但潜在的作用可能在于通过组织特异性的可变剪接或表达调控来影响LOX的生物学活性。但无论是在正常或病理情况下，关于眼组织中LOX的信息很少。近年有相关研究发现LOX可能参与许多眼部疾病的发生和发展，现就以近年来LOX参与的眼部疾病的研究进展做一综述。
[Key word]
[Abstract]
Lysyl oxidase(LOX), an amino oxidase with copper binding site outside the cell, has been confirmed that may be involved in the pathogenesis of many diseases by a large number of studies. At present, although the potential mechanism of common variants of LOX in the development of disease is still unknown, but the potential role may be to affect the biological activity of LOX through tissue-specific alternative splicing or expression regulation.However, no matter under normal or pathological conditions, there is still little information about LOX in eye tissue yet.In recent years, it has been found that LOX may be involved in the occurrence and development of many eye diseases in related studies. Based on this, the review will summarize the research progress of eye diseases in which LOX is involved of recent years.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81660162); 贵州省科技计划项目{No.黔科合基础\〖2020\〗1Y327}; 遵义市科技计划项目\〖No.遵市科合平台HZ字(2019)2号、遵市科合(2018)4号\〗
