[关键词]
[摘要]
视神经脊髓炎(NMO)为亚裔人群高发、神经眼科交叉、体液免疫主导的炎症性中枢神经系统星形胶质细胞病，因其高致病性、高复发风险和预后差而备受关注。NMO相关性视神经炎(NMO-ON)患者很难从常规治疗中获益，多遗留不同程度的视神经萎缩。NMO-ON研究的一个局限是实验模型的不足，故本文就NMO及NMO-ON实验模型的研究进展及应用作一综述，旨在探究NMO视功能损害的病理学机制及可能的治疗方法。
[Key word]
[Abstract]
Neuromyelitis optica(NMO)is an inflammatory central nervous system(CNS)astrocytic disease with high incidence, neuro-ophthalmic intercross, and humoral immune-dominated in Asian population. It has attracted much attention due to its high pathogenicity, high risk of recurrence, and poor prognosis. It is difficult for patients with NMO-associated optic neuritis(NMO-ON)to benefit from routine treatment, and they are often left with different degrees of optic nerve atrophy. One limitation of the study of NMO-ON is the deficiency of the experimental model. Therefore, the progress and application of NMO and NMO-ON experimental model are reviewed in this paper, aiming to explore the pathological mechanism and possible treatment of NMO visual impairment.
[中图分类号]
[基金项目]
国家自然科学基金面上项目(No.81574029)
