[关键词]
[摘要]
间充质干细胞(MSCs)具有很强的增殖能力，并且可以分化成不同类型的细胞，为动物个体发育中体细胞的更新提供了极大的可塑性。基于其独特的生物学特性，现在被用于治疗各种创伤性和退行性疾病，其临床应用潜能几乎是无限的。本文就骨髓和脂肪组织来源的两种间充质干细胞(BMSCs和ADSCs)，讨论了其应用于眼科各种疾病的临床治疗、给药方法及其获得途径和安全性的相关研究。
[Key word]
[Abstract]
Mesenchymal stem cells(MSCs)are multipotent cells with high proliferation ability that can differentiate into a variety of cell types. Thus great plasticity was provided for the regeneration of somatic cells in animal individual growth. Recently, MSCs have been applied to the treatment of traumatic and degenerative diseases on account of its distinct biologic peculiarity. The cells have tremendous potential in the clinical application. This article reviewed clinical treatment of ophthalmic diseases, administration route, methods of acquiring and security about two of MSCs derived from bone marrow and adipose tissue(BMSCs and ADSCs).
[中图分类号]
[基金项目]
国家自然科学基金资助(No.81660158); 江西省自然科学基金重大项目(No.20161ACB21017); 江西省青年科学基金(No.20151BAB215016); 江西省重点研发项目(No.20151BBG70223; 20181BBG70004); 江西省杰出青年人才计划(No.S2019RCQNB0259)
