[关键词]
[摘要]
运动干预作为一种治疗措施不仅费用低廉且容易实施，近年研究发现运动对糖尿病视网膜病变、年龄相关性黄斑变性、视网膜色素变性等视网膜疾病具有保护作用，其机制可能与增强视网膜抗氧化应激能力、减少谷氨酸分泌、通过脑源性神经生长因子(BDNF)/TrKB(tropomyosin receptor kinase B)通路抑制视网膜细胞凋亡等有关。本文从动物实验、临床研究及机制探讨等方面对近年来运动对视网膜保护作用的相关文献予以综述。
[Key word]
[Abstract]
Physical exercise is a low-cost, easy-to-implement therapeutic intervention. In recent years, it has been found that exercise has a protective effect on retinal diseases such as diabetic retinopathy, age-related macular degeneration and retinitis pigmentosa. The mechanism may be related to enhancing retinal defence against oxidative stress, reducing glutamate secretion and inhibiting retinal cell apoptosis through BDNF/TrkB pathway. This paper reviews the recent literature related to the protective effect of exercise on retina from animal experiments, clinical studies and mechanism investigation.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.81973912); 北京市自然科学基金项目(No.7192236)
