目的：定量评估健康孕妇与子痫前期孕妇脉络膜血管分层厚度的改变。方法：横断面观察性研究。纳入100例女性受试者，包括40例正常未孕者，23例健康孕妇和37例确诊为子痫前期的孕妇。通过光学相干断层扫描(SD-OCT)测量黄斑中心凹脉络膜厚度(SFCT)以及距黄斑中心凹750、1 500 μm处鼻/颞侧脉络膜厚度，分别定量评估三组受检者Sattler层(LCVT)和Haller层(MCVT)脉络膜血管厚度的差异。结果：三组平均年龄和等效球镜度数均无显著性差异(P=0.240，0.338)。健康孕妇和子痫前期孕妇胎龄无显著性差异(P=0.783)。三组受检者LCVT、MCVT和SFCT均存在显著性差异(P<0.05)。与正常未孕者相比，健康孕妇LCVT、MCVT和SFCT显著增加(P<0.05)。与健康孕妇相比，子痫前期孕妇LCVT和SFCT显著增加(P<0.05)，而MCVT则无差异(P=0.709)。结论：妊娠期和子痫前期孕妇脉络膜血管亚层厚度明显增加，脉络膜厚度(CT)的增加可能是由于Haller层增厚，且子痫前期和健康孕妇鼻侧CT的增幅大于颞侧，推测副交感神经和交感神经介导的调节作用及非血管平滑肌细胞可能在妊娠和子痫前期脉络膜血管亚层厚度的变化中发挥一定的作用。

AIM: To quantitatively assess choroid vascular sublayers in women with pre-eclampsia(PE)compared to healthy pregnant women.METHODS: This cross-sectional observational study enrolled 100 subjects, including 40 healthy non-pregnant women, 23 healthy pregnant women, and 37 women with PE. Spectral-domain optical coherence tomography(SD-OCT)was used to measure the choroidal thickness(CT)at the fovea and four additional sites that were 750 μm nasal/temporal or 1 500 μm nasal/temporal to the fovea, and designated as subfoveal choroidal thickness(SFCT), N750, T750, N1500, and T1500, respectively. The thickness of two choroidal vessel layers, Sattler's and Haller's layers, also were quantitatively assessed. RESULTS: No significant differences in mean age or spherical equivalent were observed among the three groups(P=0.240, 0.338). No difference was observed in gestational ages between the healthy pregnant women and PE patients(P=0.783). Significant differences were observed in large choroidal vessel thickness(LCVT), medium choroidal vessel thickness(MCVT), and SFCT at the five sites among the three groups(P<0.05). Compared with normal non-pregnant women, a significant increase in LCVT, MCVT, and SFCT was detected at the five sites in healthy pregnant women(P<0.05). LCVT and SFCT in PE patients were significantly greater at the five sites compared to normal pregnant women(P<0.05), while MCVT was not different(P=0.709).CONCLUSION: This study demonstrated that the vascular sublayer thickness of the choroid was significantly increased in pregnancy and PE. Moreover, the increase in CT thickness might be due to the thickening of Haller's layer. We also observed that the nasal CT increased more than the temporal CT in PE patients and normal pregnant women. We suggest that parasympathetic and sympathetic mediated regulation and nonvascular smooth muscle cells might play a role in the choroidal vascular sublayer thickness variations observed in pregnancy and PE.