黏蛋白是决定泪膜稳定性的关键因素，对维持眼表稳态至关重要。杯状细胞能够改变角膜和结膜上皮细胞分泌黏蛋白，促进干眼(DED)和眼表炎症的发生。本文基于对黏蛋白生物学的认识，就黏蛋白和眼表疾病之间的潜在联系进行总结，旨在更好地了解黏蛋白的重要性，基于眼表疾病有针对性地选择最为合适的治疗方案。

Mucin is the key factor to determine the stability of tear film and is crucial to maintain ocular surface homeostasis. Goblet cells can alter the secretion of mucin in corneal and conjunctival epithelial cells, contributing to dry eye disease and ocular surface inflammation. Based on the understanding of mucin biology, this review makes a summary on the potential relationship between mucin dysfunction and ocular surface diseases, and we hope to deepen the understanding of the importance of mucin and select the most appropriate treatment plan on the basis of ocular surface diseases.

国家自然科学基金资助项目(No.81660158)