眼科疾病的发生发展与细胞生理功能和眼组织功能异常密切相关，其中相关信号通路的调控发挥了重要作用。Rho/ROCK信号通路可参与多种细胞事件，包括诱导细胞骨架重组、细胞黏附、细胞增殖和血管生成，并可在细胞周期进展、细胞分化和细胞凋亡中发挥显著作用。研究表明，Rho/ROCK信号通路在眼组织中分布广泛，其异常活化可影响眼组织的正常生理功能，与眼病的发生发展关系紧密。本文对Rho/ROCK信号通路在眼科疾病发生发展中的作用简要综述，为临床治疗眼病提供思路。

The occurrence and development of ophthalmic diseases are closely related to the abnormality of cellular regulation and ocular tissue function, in which the relevant signaling pathways play an important role in the regulation of physiological functions. The Rho/ROCK signaling pathway is involved in a variety of cellular events, including cytoskeletal reorganization, cell adhesion, cell proliferation and angiogenesis, and also plays a significant role in cell cycle progression, cell differentiation and apoptosis. Studies have shown that the Rho/ROCK signaling pathway is widely distributed in ocular tissues, and its aberrant activation can affect the normal physiological function of ocular tissues, demonstrating it is closely related to the occurrence and development of ophthalmic diseases. This paper briefly reviews the role of Rho/ROCK signaling pathway in the occurrence and development of ophthalmic diseases, providing new insights into the clinical treatment of ophthalmic diseases.

国家重点研发计划(No.2019YFC1710200); 山东省重点研发计划(No.2019GSF108252,2017CXGC1211)