目的：探讨角膜塑形镜联合0.01%硫酸阿托品眼用凝胶对小儿近视恢复情况的影响及影响患儿疗效的因素。方法：采用前瞻性研究方法，选取2017-03/2019-03就诊于本院的近视儿童200例，根据儿童和监护人要求选择观察组(角膜塑形镜联合0.01%硫酸阿托品眼用凝胶)和对照组(仅配戴角膜塑形镜)。观察组108例纳入研究，6mo后8例舍弃，最终纳入100例完成随访。对照组92例纳入研究，6mo后5例舍弃，最终87例完成随访。收集患者治疗前及治疗后6mo最佳矫正远视力、最佳矫正近视力、裸眼视力、眼压、瞳孔直径和调节幅度及不适症状。结果：观察组患儿治疗后裸眼视力为0.12±0.05，对照组为0.19±0.07，较治疗前均显著改善(P<0.05)，且观察组显著优于对照组(P<0.05)。两组治疗后眼压均较治疗前无明显变化(P>0.05)； 观察组患儿治疗后瞳孔直径为7.01±0.66mm，相比治疗前的6.09±0.69mm显著升高(P<0.05)； 调节幅度为14.06±4.03D，相比治疗前的15.31±4.40D显著降低(P<0.05)，对照组治疗后的瞳孔直径和调节幅度与治疗前比较均无明显变化(P>0.05)。Pearson相关性分析结果表明：患儿近视控制效果与年龄、治疗前裸眼视力和散光度数呈负相关(P<0.05)，多因素Logistic回归分析结果显示年龄、治疗前裸眼视力是影响近视控制效果的因素(P<0.05)。结论：角膜塑形镜联合0.01% 硫酸阿托品眼用凝胶有助于小儿近视患者视力控制，治疗效果受到患儿年龄、治疗前裸眼视力因素影响。

AIM: To investigate the influence of orthokeratology combined with 0.01% Atropine Sulfate Eye Gel on the recovery of myopia in children and the factors influencing the curative effect of children. METHODS: Totally 200 children with myopia admitted to our hospital in 2017-03/2019-03 were selected. According to the requirements of children and guardians, the observation group(orthokeratology combined with 0.01% Atropine Sulfate Eye Gel)and the control group(only wearing orthokeratology)were selected. Totally 108 cases in the observation group were included in the study, 8 cases were abandoned after 6mo, and 100 cases were finally included to complete the follow-up. 92 cases in the control group were included in the study, 5 cases abandoned after 6mo, and 87 cases completed the follow-up. The patients' best corrected far vision, best corrected near vision, naked eye vision, intraocular pressure, pupil diameter and adjustment amplitude and discomfort symptoms after treatment were collected before and after 6mo.RESULTS: The uncorrected visual acuity of the observation group after treatment was 0.12±0.05, and that of the control group was 0.19±0.07, which were significantly higher than those before treatment(P<0.05), and the observation group was significantly higher than that of the control group(P<0.05). After treatment, the intraocular pressure of the two groups had no significant change(P>0.05); the pupil diameter of the observation group after treatment was(7.01±0.66)mm, which was significantly higher than(6.09±0.69)mm before treatment(P<0.05); the adjustment amplitude was(14.06±4.03)D, which was significantly lower than(15.31±4.40)D before treatment(P<0.05); there were no significant changes in the pupil diameter and adjustment amplitude of the control group after treatment(P>0.05). Pearson correlation analysis showed that good myopia control was negatively correlated with age, uncorrected visual acuity and astigmatism before treatment(P<0.05). Multivariate Logistic regression analysis showed that myopia control was negatively correlated with age and uncorrected visual acuity before treatment(P<0.05).CONCLUSION: Orthokeratology combined with 0.01% Atropine Sulfate Eye Gel is helpful for the control of myopia in children. The effect of treatment is influenced by the age of children and the visual acuity before treatment.