目的：探讨血清肿瘤标记物神经元特异性烯醇化酶(NSE)、糖蛋白抗原CA153、CA199在视网膜母细胞瘤(RB)患者血清中的分泌水平。方法：选取2017-10/2019-10在深圳市人民医院进行化疗且临床资料完整的RB患儿42例为研究对象，检测首次化疗前空腹静脉血血清中肿瘤标记物NSE、CA153、CA199水平，比较不同性别、不同临床分期、单双眼受累患者血清肿瘤标记物水平的差异。结果：晚期组患儿血清肿瘤标记物NSE、CA153、CA199水平均高于早中期组(49.69±18.45ng/mL vs 36.18±14.92ng/mL，22.38±12.03U/mL vs 15.10±8.32U/mL，46.44±18.76U/mL vs 30.21±24.03U/mL，P<0.05)，但不同性别、单双眼受累患儿血清各肿瘤标记物水平均无明显差异(P>0.05)。结论：血清NSE、CA153、CA199在临床晚期RB患者血清中的分泌水平明显高于早中期患者，其对RB分期诊疗可能具有重要意义。

AIM: To investigate the secretion levels of serum tumor markers neuron specific enolase(NSE), glycoprotein antigen CA153 and CA199 in patients with retinoblastoma(RB).METHODS: Data of 42 RB patients who received chemotherapy at Shenzhen People's Hospital between October 2017 and October 2019 were collected. The RB group was regrouped according to early and mid-term/advanced stages, and single/double eye involvement, the levels of serum tumor markers were compared between these subgroups and different genders.RESULTS: The levels of tumor markers NSE, CA153 and CA199 in the advanced group were higher than those in the early and mid-term groups(49.69±18.45ng/mL vs 36.18±14.92ng/mL, 22.38±12.03U/mL vs 15.10±8.32U/mL, 46.44±18.76U/mL vs 30.21±24.03U/mL, P<0.05), but there was no statistically significant difference in expression between the groups of different genders and single and binocular involvement(P>0.05).CONCLUSION: Serum NSE, CA153 and CA199 are significantly increased in advanced group than early and mid-term group, and they are of great significance in the diagnosis and treatment of RB. The difference between NSE in single and double eyes is worthy of further study.

深圳市科技研发资金知识创新计划基础研究项目(No.JCYJ20140416122811998)