目的：观察配戴角膜塑形镜后的相对周边屈光度变化，探讨该变化与眼轴改变之间的关系。方法：选取2016-05/2018-11就诊的-1.00～-6.00D的青少年近视患者104例，随机分为试验组(配戴角膜塑形镜)及对照组(配戴框架眼镜)。随访观察患者治疗1a期间的眼轴、相对周边屈光度(鼻侧30°～颞侧30°)。 结果：试验组戴镜后各时间点的相对周边屈光度呈现近视漂移状态(P<0.05)，这种变化在戴镜1mo内最为明显(P<0.05)，1mo后基本趋于稳定(P>0.05)。对照组相对周边屈光度呈现远视程度增加。1a后两组患者的眼轴及各径线相对周边屈光度的变化差异均具有统计学意义(P<0.001)。试验组治疗前后眼轴差与相对周边屈光度差值呈正相关关系(P<0.001)。结论：青少年近视患者配戴角膜塑形镜后，眼轴增长变慢，相对周边屈光度呈现近视漂移(1mo内最为明显)，两者之间存在相关关系。

AIM: To observe the changes of relative peripheral refraction(RPR)after wearing orthokeratology(OK)lens, and to explore the relationship between the changes of RPR and the axial length(AL).METHODS: Totally 104 cases of adolescent myopia(-1.00D to -6.00D)were selected from May 2016 to Nov. 2018. Then they were randomly divided into the experimental group and the control group. The experimental group wore OK lens, and the control group wore frame glasses. Their AL, RPR(N30°-T30°)were observed for 1a.RESULTS:The RPR of the experimental group showed myopic drift at each time point after wearing OK lens(P<0.05), and the change was most obvious in 1mo(P<0.05). After 1mo, the RPR basically tended to be stable(P>0.05). The RPR of the control group showed an increase in hyperopia. One year later, there were statistical differences in the changes of AL and RPR between the two groups(P<0.001). There was a positive correlation between the changes of AL and RPR in the experimental group(P<0.001).CONCLUSION: After wearing OK lens, the AL growth slowed down, while the RPR showed myopic drift and it was most obvious in 1mo. There was a correlation between the changes of AL and RPR.

四川省教育厅项目(No.15ZA0262)