目的：通过测量青年近视人群等效球镜度(SE)、眼轴(AL)、眼压(IOP)、中央角膜厚度(CCT)、前房深度(ACD)以及平均角膜曲率(Km)，探讨屈光度与眼球生物学参数的关系。方法：回顾性分析2017-03/2019-07在兰州华厦眼科医院就诊的近视患者1 619例1 619眼的术前检查资料，根据SE将其分为低、中、高、超高度近视组。收集术前SE、AL、IOP、CCT、ACD、Km等眼球生物学参数，并分析其相关性。结果：低、中、高、超高度近视组SE分别为-2.38±0.49、-4.60±0.82、-7.40±1.08、-11.58±1.23D，AL分别为24.55±0.72、25.68±0.77、26.75±0.64、28.00±0.56mm，IOP分别为14.68±3.18、14.78±2.81、15.19±2.66、15.70±2.68mmHg，ACD分别为3.41±0.24、3.34±0.25、3.32±0.25、3.24±0.27mm，Km分别为42.96±1.22、43.02±1.43、43.29±1.47、43.56±1.47D，四组患者AL、IOP、ACD、Km均有明显差异(P<0.001)，而CCT无明显差异(P>0.05)。SE值与AL、IOP、CCT、Km呈正相关性(r=0.851、0.104、0.066、0.157，均P<0.001)，与ACD呈负相关性(r=-0.129，P<0.001)。结论：随着屈光度的增加，近视患者AL增长，Km增高，IOP增高，CCT增高，ACD变浅。

AIM: To investigate the correlation of myopia severity(SE)with axial length(AL), intraocular pressure(IOP), central corneal thickness(CCT), anterior chamber depth(ACD), and mean keratometry(Km)in young myopia patients.METHODS: In the retrospective study, we selected myopic patients who were diagnosed in Lanzhou Huaxia Eye Hospital from Mar. 2017 to Jul. 2019. They were divided into four myopia groups, A(mild), B(moderate), C(high), and D(hyper)based on the SE. We then measured and analyzed the correlation of the degree of myopia with AL, IOP, CCT, ACD, and Km. Differences between groups were analyzed by one-way analysis of variance. Relationships between the relevant factors were analyzed by Pearson correlation analysis.RESULTS: The SE were(-2.38±0.49)D,(-4.60±0.82)D,(-7.40±1.08)D and(-11.58±1.23)D in the mild, moderate, high and hyper myopia groups respectively. The AL were(24.55±0.72)mm,(25.68±0.77)mm,(26.75±0.64)mm and(28.00±0.56)mm in the respective myopia groups. The IOP were(14.68±3.18)mmHg,(14.78±2.81)mmHg,(15.19±2.66)mmHg,(15.70±2.68)mmHg in the respective myopia groups. The ACD were(3.41±0.24)mm,(3.34±0.25)mm,(3.32±0.25)mm and(3.24±0.27)mm in the respective myopia groups. The Km were(42.96±1.22)D,(43.02±1.43)D,(43.29±1.47)D and(43.56±1.47)D in the respective myopia groups. There were no significant differences for CCT among the different groups. SE was significantly positive correlated to AL(r=0.851, P<0.001), IOP(r=0.104, P<0.001), CCT(r=0.066, P<0.001)and Km(r=0.157, P<0.001); SE was negative correlated to ACD(r=-0.129, P<0.001).CONCLUSION: In our study, there is a positive correlation between the progression of myopia and the increase in AL, IOP, CCT, and Km. There is a negative correlation between myopia and ACD.