外泌体(exosomes)是一类直径50～150nm的细胞外膜泡，可以递送生物活性分子(如蛋白质、脂质、DNA、miRNA等)至靶细胞中，以发挥细胞间通讯作用。外泌体介导的细胞间通讯影响靶细胞的凋亡、侵袭、迁移、免疫应答及氧化损伤修复等功能。近年来外泌体研究在眼科学领域迅速开展，本文总结了在眼科疾病中外泌体相关研究的最新进展。

Exosomes are extracellular vesicles of sizes ranging from 50-150nm in diameter. Exosomes can deliver bioactive molecules(e.g. proteins, lipids, DNA, microRNA, etc.)into target cells which play an important role in cell-cell communication. Researches demonstrated that exosomes mediated cell-cell communication can impact cell apoptosis, invasion, migration, immune response and oxidative repair ability of recipient cells. Recently, researches on exosomes developed rapidly in the field of ophthalmology. This review summarized the latest research progress of exosomes in ophthalmic diseases.

国家自然科学基金资助项目(No.81974129)