干眼是伴有眼部不适症状，严重影响患者工作和生活的一种常见眼表疾病。干眼的病因众多且易复发，难以有效地治愈。随着聚合酶链式反应(PCR)和免疫印迹实验(Western blot)等技术在干眼研究领域的运用，宏基因组学、基因工程动物及基因转染等基因组学事件在干眼研究中得到了进一步的探索。本文旨在总结基因组学在干眼研究中的应用进展，为进一步揭示干眼发生的危险因素和发病机制，探索有效治疗干眼的新型药物和疗法提供重要依据。

Dry eye is a common ocular surface disease accompanied by ocular discomfort, which severely affects the work and life of patients. There are numerous causes of dry eye, and the disease is easy to recur, which is difficult to cure effectively. With the application of polymerase chain reaction(PCR)and western blotting in study of dry eye, genomics events such as metagenomics, genetically engineered animals and gene transfection have been further explored in dry eye research. Advances in the application of genomics for dry eye are summarized, in order to provide an important basis for further revealing the risk factors and pathogenesis, and exploring new drugs and therapies for effective treatment of dry eye.

国家自然科学基金资助项目(No.81774419)