[关键词]
[摘要]
血-视网膜内屏障是维持视网膜内环境稳态的重要结构基础，其完整的结构和功能仍缺乏更为深入的研究。体外血-视网膜内屏障模型具有可控、高效、快速、稳定等特点，已成为研究屏障具体构成和功能的一种有效工具。本文主要对血-视网膜内屏障的结构组成、功能以及体外模型的构建进行综述，有助于推进血-视网膜内屏障生理生化、病理药理及临床等方面的研究，并为糖尿病视网膜病变等眼底血管性疾病的研究提供一种共性与关键的实验基础。
[Key word]
[Abstract]
The blood-retinal barrier is an important structural basis for maintaining the homeostasis of the retinal environment, but there is still a lack of further research on its complete structure and function. The in vitro blood-retinal barrier model has the characteristics of controllable, efficient, fast and stable, and has become an effective tool to study the specific structure and function of the barrier. This paper mainly reviews the structure, function and in vitro model of blood-retinal barrier, which is helpful to promote the study of physiology, biochemistry, pathopharmacology and clinic of blood-retinal barrier. It also provides a common and key experimental basis for the study of fundus vascular diseases such as diabetic retinopathy.
[中图分类号]
[基金项目]
国家自然科学基金面上项目(No. 81473735)
