[关键词]
[摘要]
青光眼是世界上首要的不可逆性致盲性眼病，药物及手术治疗虽可控制眼压，但并不能有效逆转视网膜神经节细胞的凋亡。随着遗传学及分子生物学研究的进展，对于青光眼发病机制的研究也逐步深入。本文将对近年来国内外有关Rho/ROCK、TGF-β/Smad、PI3K/Akt、Nrf2/Keap1/ARE和BDNF/TrkB等信号转导通路在青光眼发病机制中的作用进行综述。有望为青光眼的治疗提供新的思路和方法。
[Key word]
[Abstract]
Glaucoma is the leading cause of irreversible vision loss in the world. Drugs and surgery can be used to control intraocular pressure, however, they can't reverse the apoptosis of retinal ganglion cells effectively. With the development of genetics and molecular biology, a large amount of research on the pathogenesis of glaucoma has been conducted. This review discusses the potential role of Rho/ROCK, TGF-β/Smad, PI3K/Akt, Nrf2/Keap1/ARE and BDNF/TrkB signaling pathways in the pathogenesis of glaucoma, and expects to provide new ideas and methods for the treatment of glaucoma.
[中图分类号]
[基金项目]
陕西省重点研发计划(No.2017ZDXM-SF-067)
