目的：系统评价中国人群年龄相关性黄斑变性(ARMD)的危险因素。

方法：计算机检索PubMed、EMbase、Web of Science、The Cochrane Library、CBM、CNKI、WanFang Data和VIP数据库，搜集有关中国人群ARMD危险因素的研究，检索时间均从建库至2019-12。由2位研究者独立筛选文献、提取资料、并按照纳入排除标准对文献进行质量评价，采用RevMan 5.3软件进行Meta分析。

结果：共纳入27个研究，共计204 767例研究对象，涉及10个危险因素。Meta分析结果显示：吸烟\〖OR=2.30，95%CI(1.95，2.71)，P<0.0001\〗、高血压\〖OR=1.55，95%CI(1.23，1.95)，P=0.0002\〗、HTRA1 rs11200638基因\〖OR=4.35，95%CI(2.35，7.48)，P<0.0001\〗、CFH Y402H基因\〖OR=3.28，95%CI(2.51，4.28)，P<0.00001\〗、LOC387715 rs10490924基因\〖OR=7.09，95%CI(3.48，14.44)，P<0.00001\〗是中国人群ARMD的危险因素。描述性分析结果显示：糖尿病性视网膜病变(DR)、白内障手术、二氧化氮(NO₂)、一氧化碳(CO)、乙肝病毒感染(HBV)与中国人群ARMD有关。

结论：吸烟、高血压、HTRA1 rs11200638基因、CFH Y402H基因、LOC387715 rs10490924基因、DR、白内障手术、NO₂、CO、HBV感染是中国人群ARMD的危险因素。

METHODS:PubMed, EMbase, Web of Science, The Cochrane Library, CBM, CNKI, Wan Fang Data VIP databases were electronically searched to collect case-control studies, cohort studies and cross-sectional studies on the risk factors of ARMD in China from inception to December, 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies, then, Meta-analysis was performed by using RevMan 5.3 software.

RESULTS: A total of 27 studies involving 204 767 objects and 10 risk factors were included. The results of Meta-analysis showed that smoking \〖OR=2.30, 95%CI (1.95, 2.71), P<0.0001\〗, hypertension \〖OR=1.55, 95%CI (1.23, 1.95), P=0.0002\〗, HTRA1 rs11200638\〖OR=4.35, 95%CI (2.35, 7.48), P<0.0001\〗, CFH Y402H \〖OR=3.28, 95%CI (2.51, 4.28), P<0.00001\〗, LOC387715 rs10490924 \〖OR=7.09, 95%CI (3.48, 14.44), P<0.00001\〗. Desciptive analysis results showed that DR, Cataract surgery, NO₂, CO and HBV infection were risk factors of ARMD in China.

CONCLUSION: Current evidence shows that smoking, hypertension, HTRA1 rs11200638, CFH Y402H, LOC387715 rs10490924, DR, cataract surgery, NO₂, CO and HBV infection are the risk factors of ARMD in China.