目的：评估无黏弹剂微切口中心孔型植入式透镜(ICL)V4c植入术后拱高对角膜内皮细胞的影响。

方法：前瞻性非随机对照研究。选取2017-11/2018-02于我院行无黏弹剂微切口ICL V4c植入术的近视患者70例137眼，按照术后拱高的大小分为低拱高组(100μm<拱高≤250μm，37眼)、中拱高组(250μm<拱高≤750μm，69眼)、高拱高组(750μm<拱高≤900μm，31眼)。术后随访1a，观察角膜内皮细胞计数及前房参数的变化。

结果：术后1wk，三组患者前房深度、前房容积、前房角角度均较术前减小(P<0.05)。三组患者手术前后不同时间的角膜内皮细胞计数无明显差异，术后1wk， 3mo， 1a低拱高组角膜内皮细胞丢失率分别约为1.2%、1.5%、1.7%，中拱高组分别约为0.5%、0.7%、1.0%，高拱高组分别约为1.1%、1.3%、1.4%。

结论：无黏弹剂微切口ICL V4c植入术后早期拱高对角膜内皮细胞无明显影响。

METHODS: Prospective non-randomized controlled study. A total of 70 patients(137 eyes)with myopia who underwent ICL V4c implantation in our hospital from November 2017 to February 2018 were divided into low vault group(100μmRESULTS:At 1wk after operation, the anterior chamber depth, anterior chamber volume and anterior chamber angle of the three groups were all decreased compared with those before operation(P<0.05). There was no significant difference in corneal endothelial cell count among the three groups at different time points before and after surgery. The loss rate of corneal endothelial cells in the low vault group at 1wk, 3mo and 1a after surgery were about 1.2%, 1.5% and 1.7%, respectively. The loss rate of corneal endothelial cells in the middle vault group were about 0.5%, 0.7% and 1.0%, respectively. The loss rate of corneal endothelial cells in the high vault group were about 1.1%, 1.3% and 1.4%, respectively.

CONCLUSION:The vault in early period after ICL V4c implantation without viscoelastic microincision had no significant effect on corneal endothelial cells.