[关键词]
[摘要]
糖尿病性视网膜病变是糖尿病最常见和严重的眼部并发症，也是工作年龄人群致盲的主要原因。视网膜内几乎所有类型的细胞均受累及，导致视网膜“神经-血管单元”和“神经-胶质网络”破坏及功能障碍。促红细胞生成素(erythropoietin， EPO)是一种糖蛋白激素，研究发现EPO在多种中枢神经系统疾病中发挥神经保护、神经营养、抗炎、抗凋亡及抗氧化等作用。本文主要就EPO维持糖尿病性视网膜病变状态下视网膜的功能进行综述，以期为糖尿病性视网膜病变的临床治疗提供新思路。
[Key word]
[Abstract]
Diabetic retinopathy(DR)is the most common complication of diabetes mellitus and remains the leading cause of blindness in working-age population. DR affects almost all the retinal cells, leading to the disruption and dysfunction of neurovascular unit and the neural-glial network. Erythropoietin(EPO), a glycoprotein hormone, plays a pivotal role in neuroprotection, neurotrophy, anti-inflammation, anti-apoptosis and anti-oxidation etc., in various central nervous system diseases. This review discussed the protective effect of EPO in DR so as to provide new options for DR treatment.
[中图分类号]
[基金项目]
国家自然科学基金面上项目(No.81570852)
