干眼作为多因素引起的复杂疾病，其发病机制也复杂多样，目前认为泪膜不稳定、泪液渗透压升高、眼表炎性和神经异常等为干眼公认的发病机制，并且炎症作为干眼生理病理发病的关键机制被得到证实，为了更全面地了解干眼的炎症级联反应，此次重点讨论与干眼相关的关键因子和细胞介质的作用以及相关抗炎治疗。

Dry eye is a complex disease caused by multiple factors which pathogenesis is complex and diverse. At present, the tear film instability, the increase of tear osmotic pressure, ocular surface inflammation and neurological abnormalities are recognized as the pathogenesis of dry eye. Particularly, inflammation has been confirmed as the key mechanism for the pathogenesis of the dry eye. In this case, this study focuses on discussing the role of critical factors and cell mediators related to dry eye and the anti-inflammatory treatments for it to understand the inflammatory cascade of the dry eye more comprehensively.

国家自然科学基金项目(No.81774419)