后发性白内障又称后囊膜混浊(posterior capsular opacification，PCO)是白内障摘除术后最为常见的并发症，严重影响患者的生活质量。目前尚无防止其发生的有效措施，临床上多用手术或Nd：YAG激光治疗，现在亟需新的治疗方案。Hippo信号通路参与了哺乳动物多种细胞和器官的稳态调控，最近研究表明Hippo信号通路可调控晶状体上皮细胞(LECs)增殖、凋亡、分化等行为，Hippo信号通路可能为后发性白内障治疗提供新的靶点，本文论述了Hippo信号通路的组成、调节机制及其在后发性白内障中与其他信号通路的相互关系及相关药物治疗，以期为后发性白内障防治提供更广阔的思路。

Posterior capsular opacification is the most common complication after cataract extraction, which seriously influences the quality of life of patients. At present, there is no effective measure to prevent posterior capsular opacification. Surgery or Nd:YAG laser is often used in clinical, and a new treatment is urgently needed. Hippo signaling pathway is involved in the steady-state regulation of many mammalian cells and organs. Recent studies have shown that Hippo signaling pathway can regulate the proliferation, apoptosis, differentiation and other behaviors of lens epithelial cells. Hippo signaling pathway may provide a new target in the treatment of posterior capsular opacification. This article reviews the composition, regulatory mechanism of Hippo signaling pathway and its application in posterior capsular opacification. In order to provide a broader idea for the prevention and treatment of posterior capsular opacification.

广西自然科学基金项目(No.2015GXNSFAA139179)