目的：分析影响白内障患者超声乳化吸除联合人工晶状体植入术后发生角膜水肿的危险因素。方法：回顾性分析2018-03/2020-09在我院行超声乳化吸除联合人工晶状体植入术治疗的白内障患者623例957眼临床资料，术后前3d内观察到角膜水肿者82例82眼，未观察到角膜水肿者541例875眼。收集两组患者术前、术中、术后相关指标纳入Logistic回归模型筛选高危因素。结果：Logistic回归分析结果显示，年龄(OR=1.162)、Emery晶状体核硬度分级(OR=1.301)、灌注时间(OR=1.172)均是导致超声乳化吸除联合人工晶状体植入术后发生角膜水肿的危险因素，而前房深度(OR=0.651)则是避免其发生的保护因素(P<0.05)。结论：白内障患者超声乳化吸除联合人工晶状体植入术后发生角膜水肿涉及因素较为复杂，临床需对高危患者提高警惕，围术期采取相应防范措施，以促进患者术后视功能快速恢复。

AIM: To analyze the risk factors of corneal edema after phacoemulsification and intraocular lens implantation in patients with cataract. METHODS: The clinical data of 623 patients with cataract(957 eyes)who underwent phacoemulsification and intraocular lens implantation in our hospital between March 2018 and September 2020 were retrospectively analyzed. Patients with corneal edema observed at any time within the first three days after surgery were included in corneal edema group(82 cases, 82 eyes), and patients without corneal edema were enrolled as non-corneal edema group(541 cases, 875 eyes). The preoperative, intraoperative and postoperative related indexes of the two groups were collected and included in Logistic regression model to screen the high-risk factors. RESULTS: Logistics regression analysis showed that age(OR=1.162), Emery lens nuclear hardness grading(OR=1.301)and perfusion time(OR=1.172)were independent risk factors for corneal edema after phacoemulsification and intraocular lens implantation, and the anterior chamber depth(OR=0.651)were independent protective factors avoiding occurrence(P<0.05).CONCLUSION:The factors involved in corneal edema after phacoemulsification and intraocular lens implantation are complicated in patients with cataract. It is necessary to be vigilant for high-risk patients in clinical practice and take preventive measures during perioperative period so as to promote rapid recovery of prognosis and visual function.

黔东南州科技计划项目[No.黔东南科合J字(2019)025号]