[关键词]
[摘要]
肺腺癌转移相关转录本1(metastasis-associated lung adenocarcinoma transcript 1， MALAT1)是最早鉴定出的与人类疾病相关的长链非编码RNA(LncRNA)之一，与LncRNA家族中的大多数成员不同，MALAT1在几乎所有人体组织中都以相对较高的水平表达。目前已知MALAT1在肿瘤、心血管疾病、神经系统疾病等多种疾病的病理生理过程中起着至关重要的作用，近年来有研究发现MALAT1可能在许多眼部疾病(如糖尿病视网膜病变、白内障、青光眼、视网膜母细胞瘤、新生儿视网膜病变等)的病理发展过程中扮演着重要角色，有望成为诊断和治疗眼部疾病的有效靶点。现就以近年来MALAT1参与的眼部疾病的研究进展做一综述。
[Key word]
[Abstract]
Metastasis-associated lung adenocarcinoma transcript 1(MALAT1)is one of the first identified LncRNA associated with human diseases. Unlike most members of the LncRNA family, MALAT1 is found in almost all human tissues and expressed at a relatively high level. At present, MALAT1 is known to play a vital role in the pathophysiological process of many diseases such as tumors, cardiovascular diseases, and nervous system diseases. In recent years, studies have found that MALAT1 may be involved in many ocular diseases(such as diabetic retinopathy, cataracts, glaucoma, retinoblastoma, neonatal retinopathy, etc.)play an important role in the pathological development process, and it is expected to become an effective target for the diagnosis and treatment of eye diseases. This article summarizes the research progress of eye diseases in which MALAT1 has participated in recent years.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81660162); 国家眼部疾病临床医学研究中心遵义分中心培育项目\〖No.遵市科合平台HZ字(2019)2号\〗; 沪遵眼病防治临床医学科技创新中心\〖No.遵市科合(2018)4号\〗
