[关键词]
[摘要]
脑源性神经营养因子(BDNF)是一种碱性蛋白质，也是神经营养因子家族的一员，在神经元的发育、分化和维持中起重要作用。大量研究已经证实BDNF参与帕金森病、阿尔茨海默病等神经退行性疾病的发生发展且具有神经保护作用。BDNF在视网膜中主要由视网膜神经节细胞、无长突细胞、星形胶质细胞、视网膜胶质细胞(Müller细胞)和光感受器产生，近年来相关研究发现BDNF参与青光眼、糖尿病视网膜病变(DR)等眼部疾病的发生发展且可能具有诊断作用，这将有利于及早对患者进行干预避免其发展至晚期青光眼或DR。另一方面，基于BDNF的治疗方法在青光眼、DR和弱视的体内体外实验中取得了很好的结果，可能为这些眼部疾病的治疗提供更多的选择。现就近年来BDNF参与眼部疾病的研究进展做一综述。
[Key word]
[Abstract]
Brain-derived neurotrophic factor(BDNF)is a basic protein, and a member of neurotrophic factor family, which plays an important role in the development, differentiation and maintenance of neurons. A large number of studies have confirmed that BDNF is involved in the occurrence and development of neurodegenerative diseases such as Parkinson's disease and Alheimer's disease, and has a neuroprotective effect. In the retina, BDNF is mainly produced by retinal ganglion cells, amacrine cells, astrocytes, retinal glial cells(Müller cells)and photoreceptors. In recent years, related studies have found that BDNF is involved in the occurrence and development of glaucoma, diabetic retinopathy(DR)and other ocular diseases, and may have a diagnostic role, which will be beneficial to early intervention of patients to avoid the development of advanced glaucoma or DR. On the other hand, BDNF-based therapies have achieved good results in in vitro and in vivo experiments of glaucoma, DR and amblyopia, which may provide more choices for the treatment of these ocular diseases. In this manuscript, the research progresses of BDNF in ocular diseases in recent years were reviewed.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81660162); 贵州省科技计划项目{No.黔科合基础\〖2020\〗1Y327}; 贵州省健康委科学技术基金项目(No.gzwjkj2020-1-155)
