方法：前瞻性研究。收集2018-05/2019-08至我院治疗的7～14岁中低度青少年近视患者215例。行全面眼科检查后，根据检查结果、患者及家长依从性等综合评估，其中113例患者配戴角膜塑形镜，102例患者配戴框架眼镜。配戴期间规律复诊，测量角膜塑形镜组戴镜前，戴镜后1、3、6mo，1a时的调节幅度及1a后两组眼轴的改变。

结果：随访1a后，角膜塑形镜组共100例100眼完成随访， 13例13眼失访。框架眼镜组共77例77眼完成随访，25例25眼失访。配戴角膜塑形镜前，患者调节幅度为13.57±2.47D，戴镜后1、3、6mo，1a后调节幅度均较戴镜前显著提高(均P<0.005)，调节幅度在戴镜6mo时达到峰值，戴镜1a(15.44±2.35D)较戴镜6mo(15.74±2.32D)略有下降。配戴角膜塑形镜1a后眼轴增长明显小于框架眼镜组(0.13±0.15 vs 0.50±0.28mm，P<0.001)。

结论：中低度青少年近视患者在配戴角膜塑形镜后伴有调节幅度的提高。配戴角膜塑形镜能够控制眼轴的增长，是目前较为有效地延缓青少年近视进展的方法之一。

METHODS: Prospective study, 215 pre-adolescent myopia aged 7-14 years old were enrolled in the study from May 2018 to August 2019. Every subject was measured for comprehensive eye examination. And according to the above measurements and the compliance of children and their parents, 113 patients who matched the inclusion criteria accepted treatment of orthokeratology(ortho-k group)and the other 102 subjects were selected to wear spectacle(spectacle group). During regular follow-up visits, AA was measured respectively at pre-wear, 1, 3, 6mo and 1a after orthokeratology. AL was measured at baseline and after 1a. The changes were evaluated and compared between the orthokeratology and spectacle group.

RESULTS: After 1a follow-up, 100 eyes of 100 subjects in the ortho-k group completed the follow-up, and 13 eyes of 13 subjects were withdrawn from the study. In the spectacle group, 77 eyes of 77 subjects completed the study, and 25 eyes of 25 subjects were withdrawn. At baseline, the AA of myopia was 13.57±2.47D, the AA after 1, 3 and 6mo, 1a was significantly higher than before(all P<0.005). It reached its peak after 6mo treatment(15.74±2.32 D), and it slightly decreased at 1a treatment(15.44±2.35 D), compared with 6mo treatment. The axial elongation in orthokeratology group was significant smaller than in spectacle group during the 1a study period(0.13±0.15mm vs 0.50±0.28mm, P<0.001).

CONCLUSION: AA was improved after orthokeratology in pre-adolescents. Orthokeratology suppressed axial elongation in myopic, suggesting that it is one of the effective treatments in slowing the progression of myopia in pre-adolescents.