目的：探讨丝裂霉素对经泪小管激光泪囊鼻腔造孔术(TL-DCR)的疗效影响，并结合PubMed数据库2011-2021年发表的相关文章来阐明丝裂霉素在TL-DCR手术中的作用。

方法：回顾性分析2008-01/2019-07接受TL-DCR手术的120例患者病历资料，根据术中是否使用丝裂霉素将患者分为丝裂霉素组和非丝裂霉素组。

结果：丝裂霉素组的成功率为71.9%，非丝裂霉素组的成功率为71.0%。

结论：两组患者手术成功率无明显差异。2011-2021年PubMed数据库中关于丝裂霉素在TL-DCR手术中的作用的文章仅2篇，且研究结果相反，因此丝裂霉素在TL-DCR手术中的作用尚不明确。

AIM: To investigate if mitomycin reduces or not the probability of developing synechiae and granulomas in transcanalicular diode laser dacryocystorhinostomy. Also, we want to clarify the usefulness of mitomycin in that procedure by searching in PubMed between 2011 and 2021.

METHODS: A retrospective case series study of 120 transcanalicular diode laser dacryocystorhinostomy was performed from January 2008 to July 2019. Patients were divided into two groups: one group was operated on with mitomycin and the other group was operated on without mitomycin.

RESULTS: The success rate was 71.9% in the mitomycin group and 71.0% in the non- mitomycin group.

CONCLUSION: No statistically significant differences in the outcomes of the two groups were found. Only two opposing articles regarding the use of mitomycin in transcanalicular diode laser dacryocystorhinostomy were found in PubMed between 2011 and 2021, so the use of mitomycin is still unclear.