[关键词]
[摘要]
据统计，目前约有46%～64%的糖尿病患者罹患糖尿病性角膜病变。随着糖尿病患病率的日益攀升，糖尿病性角膜病变逐渐受到眼科医生的重视，但其发病机制尚未明确。氧化应激是机体内活性氧和活性氮产生过多，从而损害机体组织细胞的一种病理过程，其参与众多疾病的发生发展，在糖尿病眼部并发症中亦扮演重要角色。本文回顾氧化应激在糖尿病性角膜病变发病机制以及治疗中的研究进展，希望对临床诊疗有所助益。
[Key word]
[Abstract]
It is estimated that currently, about 46%-64% of patients with diabetes mellitus(DM)suffer from diabetic keratopathy(DK). With the increasing prevalence of DM, DK has gradually been concerned by ophthalmologists. Nevertheless, its pathogenesis is not yet clear. Oxidative stress is a pathological process that causes excessive production of reactive oxygen species(ROS)and reactive nitrogen species(RNS)in the body, which damages tissues and cells. It participates in the occurrence and development of many diseases, including the ocular complications of DM. This study aims to review the research progress of oxidative stress in the pathogenesis and the treatment of diabetic corneal lesions, thus providing references for clinical diagnosis and treatment of DK.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.81770899)
