[关键词]
[摘要]
人类免疫缺陷病毒(human immunodeficiency virus， HIV)感染患者眼部病变因其对患者生存质量的影响日益引起学者关注。随着HIV治疗方法的不断改善，眼部机会性感染疾病减少，而HIV相关视网膜神经病变越来越受到学者关注。研究发现HIV相关视网膜神经病变包括神经纤维层变薄，血管改变等一系列视网膜视神经结构改变，导致患者视敏感度下降、视野缺损、色觉障碍等。而HIV相关视网膜视神经病变发病机制尚未完全明确，研究发现可能与HIV病毒直接破坏视网膜视神经组织，慢性炎症，血-视网膜屏障破坏等相关。了解HIV相关视网膜视神经病变的病变特点及可能的机制，有望为疾病的治疗提供新思路与途径，提高HIV感染患者的生存质量。
[Key word]
[Abstract]
Ocular diseases in human immunodeficiency virus(HIV)infected patients have attracted increasing attention due to their impact on quality of life. As HIV treatment continues to improve, opportunistic eye infections are decreasing, while HIV-associated retinopathy is becoming a growing concern. HIV-associated retinopathy, including a series of structural changes in the retina and optic nerves(thinning of the nerve fiber layer, changing in blood vessels), has been found to cause decreased visual sensitivity, visual field defect, color vision disorder. However, the pathogenesis of HIV-associated neuroretinal disorder has not been fully clarified, and the existing findings may be related to direct destruction of retinal optic nerve tissue by HIV virus, chronic inflammation, and destruction of the blood-retina barrier. Understanding the pathological characteristics and possible mechanisms of HIV-associated neuroretinal disorder is expected to provide new ideas and approaches for the treatment of the disease and improve the quality of life of HIV-infected patients.
[中图分类号]
[基金项目]
云南省眼病临床医学中心开放课题(No.YXZX-09,YXZX-10)
