方法：前瞻性临床研究。选取2017-03/2018-12于我院眼科确诊的年龄在10～20岁的近视患者220例，其中双眼屈光参差度数的差值<1.00D为无屈光参差组76例； 1.00～<1.75D为轻度屈光参差组60例； 2.00～<2.75D为中度屈光参差组51例； ≥3.00D为重度屈光参差组33例。根据近视矫正方式分为角膜塑形镜组88例与框架镜组132例，比较两组患者在近视矫正3mo后近立体视功能。

结果：框架镜组中，不同程度屈光参差组间的近立体视功能有差异(P<0.001)。角膜塑形镜组中，不同程度屈光参差组间的近立体视功能无差异(P=0.765)。在无屈光参差组与轻度屈光参差组中，角膜塑形镜组与框架镜组之间的近立体视功能无差异(P=0.109、0.052)； 在中度与高度屈光参差组中，角膜塑形镜组的近立体视功能好于框架镜组(P<0.001)。

结论：青少年近视性屈光参差患者配戴角膜塑形镜在近立体视功能方面优于框架眼镜，特别在中度与重度屈光参差组。

METHODS:In this prospective clinical research,220 patients aged 10-20 years old with myopic anisometropia were recruited between March 2017 and December 2018. All the patients were divided into four groups according to the difference of cycloplegic spherical equivalent refractive(SER)error between the two eyes: group of 76 cases without anisometropia(SER error difference less than 1.00D), group of 60 cases with mild anisometropia(SER error difference of 1.00-<1.75D), group of 51 cases with moderate anisometropia(SER error difference of 2.00-<2.75D), and group of 33 cases with severe anisometropia(SER error difference of 3.00D or more). With regards the different optical correction approaches for myopia, 88 cases were categorized into the orthokeratology group and 132 cases into the spectacle group, the stereoacuity values at 3mo after correction were compared between the orthokeratology group and the spectacle group to see whether statistically significant difference existed.

RESULTS:In the group of spectacle correction, there was significant statistical difference existed between the four sub-groups for the near stereoscopic visual function(P<0.001). In the group of orthokeratology correction, there was no statistical difference existed between the four sub-groups for the near stereoscopic visual function(P=0.765). In both non-anisometropia and mild anisometropia groups, there was no statistical difference between the orthokeratology correction and spectacle correction sub-groups for the near stereoacuity values(P=0.109,P=0.052). However, in the moderate and severe anisometropia groups, orthokeratology group had better near stereoscopic vision than spectacle group(P<0.001).

CONCLUSION: Adolescents with myopic anisometropia corrected by orthokeratology lens were better at near stereoscopic visual function than corrected by spectacles, especially in the moderate and severe anisometropia groups.