[关键词]
[摘要]
原发性闭角型青光眼(PACG)是临床上最常见的一种青光眼类型，全球发病率高且致盲性大，具有进行性不可逆发展的特点。PACG的发病机制复杂多样，不仅与眼部解剖结构的异常有关，如前房结构出现角膜小、短眼轴和浅前房等特征，近年研究还发现晶状体、虹膜、睫状体及脉络膜异常均与PACG的发病有关。另外PACG的发生与遗传因素和心理应激因素亦有较紧密的关系，本文结合文献报道较为全面地从解剖特征、遗传因素、心理应激三个方面对PACG的发病机制做了简要论述，希望籍此为青光眼的早期诊断和治疗提供有益的理论支撑。
[Key word]
[Abstract]
Primary angle-closure glaucoma(PACG)is the most common type of glaucoma in clinical. It is characterized by progressive and irreversible development with high global incidence and high possibility of blindness. The pathogenesis of PACG is complicated. It is not only associated with the abnormality of the ocular anatomy, such as the small cornea, short eye axis and shallow anterior chamber, but also found that the abnormality of the lens, iris, ciliary body and choroid are related to the pathogenesis of PACG in recent years. Moreover, the occurrence of PACG is also closely related to genetic and psychological stress factors. Our study summarized some literatures and made a brief discussion on the pathogenesis of PACG from the three aspects of anatomical characteristics, genetic factors, and psychological stress. We hope to provide useful theoretical support for the early diagnosis and treatment of glaucoma.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.31502059); 湖北省教育厅科学研究计划指导性项目(No.B2015447)
