[关键词]
[摘要]
睑板腺功能障碍(meibomian gland dysfunction， MGD)是一种以睑板腺终末导管阻塞和(或)睑酯分泌的质或量异常为主要特征的慢性、弥漫性睑板腺病变，是引起蒸发过强型干眼的主要原因，也是十分常见的眼表疾病。MGD可引起眼表睑酯异常和细菌增殖，进而引起相关眼表体征和症状。临床上，常采用局部物理、药物和全身药物等方式治疗MGD。抗生素作为一种有效的杀菌药物，通过局部或全身使用抗生素，可以抑制眼表细菌增殖，调节眼表睑酯异常和菌群微环境，进而缓解与改善MGD的体征与症状。目前，不同种类抗生素治疗MGD的有效性已经得到证实，本文从局部或全身使用抗生素的角度出发，对各类抗生素治疗MGD的机制、方式方法和疗效等方面进行综述，为临床治疗MGD提供新的治疗参考。
[Key word]
[Abstract]
Meibomian gland dysfunction(MGD)is a chronic, diffuse blepharoplasty that is characterized by obstruction of the terminal ducts of the blepharoplasty gland and abnormal lid ester secretion, which is a common ocular surface disease as well as the major cause of hyper evaporation type dry eye. MGD can cause ocular surface lid ester abnormalities and bacterial proliferation, which in turn leads to associated ocular symptoms. Physical therapies and medicines are widely used to treat MGD in clinics. Through the topical or systemic use of antibiotics that are effective anti-bacteria medicine, ocular surface symptoms caused by MGD-induced bacterial proliferation and abnormal eyelid lipids can be alleviated. Currently, the effectiveness of various types of antibiotics in treating MGD has been demonstrated. In this review, the mechanism, modality, and efficacy of various antibiotics in the treatment of MGD were highlighted and summarized from the perspective of topical or systemic use of antibiotics, which can provide promising guidance for clinical treatments of MGD.
[中图分类号]
[基金项目]
天津市临床重点学科(专科)建设项目(No.TJLCZDXKM013)
