方法：回顾性病例对照研究。选取2020-07/2021-10我院2型糖尿病患者184例，完成眼表检查后根据是否合并MGD分为MGD组(94例)和对照组(90例)。检查两组患者睑板腺情况，采集BMI、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)。比较两组患者MGD与血脂水平的关系。采用多因素Logistic回归分析MGD发病的危险因素。

结果：MGD组患者HbA1c、TC、TG、LDL-C分别为8.30%±1.95%、5.72±1.21、2.16±1.05、3.42±1.10mmol/L均明显高于对照组(7.26%±1.18%、4.82±1.19、1.48±0.71、2.75±1.00mmol/L，均P<0.001)，两组间HDL-C无差异(P>0.05)。多因素Logistic回归分析显示，高TC血症(OR：5.846； 95%CI：1.867～18.306； P<0.001)、高TG血症(OR：5.822； 95%CI：2.654～12.774； P=0.002)为MGD发病的危险因素。

结论：2型糖尿病人群中MGD的患病与多项血脂异常均具有相关性，高TC血症、高TG血症可增加2型糖尿病合并MGD的患病风险。

METHODS: A case-control study was performed which recruited 184 patients with T2DM admitted to hospital from July 2020 to October 2021. After completing the ocular surface examination, subjects were divided into MGD group(94 cases)and control group(90 cases)according to whether MGD was combined. The body mass index(BMI), fasting blood glucose(FBG), glycosylated hemoglobin A1c(HbA1c), total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)were examined for the condition of meibomian glands and collected between the two groups of patients. The relationship between MGD and blood lipid levels was compared between the two groups. Multivariate Logistic regression was used to analyze the risk factors of MGD.

RESULTS: The HbA1c, TC, TG, LDL-C in MGD group were 8.30%±1.95%, 5.72±1.21, 2.16±1.05, 3.42±1.10mmol/L, all significantly higher than control group(7.26%±1.18%, 4.82±1.19, 1.48±0.71, 2.75±1.00mmol/L, all P<0.001), there were no statistically significant in HDL-C between the two groups(P>0.05). Multivariate Logistic regression analysis revealed that the risk factors for the onset of MGD was significantly associated with higher blood levels of TC(OR: 5.846; 95%CI: 1.867-18.306; P<0.001)and the higher blood levels of TG(OR: 5.822; 95%CI: 2.654-12.774; P=0.002).

CONCLUSION: T2DM patients with MGD are related to a number of dyslipidemias, and the TC hyperlipidemia and TG hyperlipidemia are significantly associated with an increase risk of MGD in patients with T2DM.