目的：应用可视化角膜生物力学分析仪(Corvis ST)测量轻中度近视儿童的角膜生物力学参数与角膜高阶像差(HOAs)的相关性。

方法：横断面研究。连续收集2021-04/07在天津医科大学眼科医院视光中心就诊的儿童近视患者255例的病例资料，均取右眼进行分析。应用Corvis ST测量角膜生物力学参数； 应用Pentacam三维眼前节分析仪测量并计算角膜总高阶像差(RMSh)、三阶像差(RMS3)、四阶像差(RMS4)。

结果：RMS3与第2次压平时间(A2T)呈正相关关系(r=0.175，P=0.009)，与眼轴长度(AL)呈负相关关系(r=-0.155，P=0.014)； RMS4与最大压陷时反向曲率半径(HCR)呈负相关关系(r=-0.165，P=0.009)； RMSh与HCR、AL呈负相关关系(r=-0.152，P=0.037； r=-0.175，P=0.005)。

结论：近视儿童角膜生物力学参数与角膜高阶像差间存在相关性，硬度较高、抗变形能力较强的角膜，RMS3、RMS4、RMSh较小。

METHODS:A cross-sectional study. A total of 255 pediatric patients with myopia enrolled from April to July 2021 in Tianjin Medical University Eye Hospital were continuously collected, and all the right eyes were taken for analysis. Corneal biomechanical parameters were obtained from Corvis ST. Pentacam three-dimensional anterior segment analyzer was used to measure total corneal higher-order aberrations(RMSh), third order aberrations(RMS3)and fourth order aberrations(RMS4).

RESULTS:RMS3 was positively correlated with the second applanation time(A2T)(r=0.175, P=0.009)and negatively correlated with the axis length(AL)(r=-0.155, P=0.014). RMS4 was negatively correlated with the highest concavity radius(HCR)(r=-0.165, P=0.009). RMSh was negatively correlated with HCR and AL(r=-0.152, P=0.037; r=-0.175, P=0.005).

CONCLUSION:There is a correlation between corneal biomechanical parameters and HOAs in children with myopia. Cornea with higher stiffness and stronger deformation resistance has smaller RMS3, RMS4 and RMSh.