[关键词]
[摘要]
干眼是一种多因素的眼表疾病，干眼的发病机制仍不完全清楚，其中炎症和免疫反应被认为是干眼发病机制的核心机制之一。神经肽是感觉神经末梢受损伤或刺激后产生的小分子肽，在触发和调节炎症反应中起重要作用，是神经系统和免疫系统之间的重要介质。最近研究发现由眼表神经分泌的神经肽被认为是干眼发病机制的重要因素。因此，本文总结了神经肽在干眼发病机制中的作用的研究，分析最新观点和研究热点，为干眼的防治提供参考。
[Key word]
[Abstract]
Dry eye(DE)is a multi-factorial ocular surface disease. The mechanisms underlying the pathogenesis of DE is still unclear. Inflammation and immune response are considered to be one of the core mechanisms among the pathogenesis of DE. Neuropeptides are small molecular peptides generated after the sensory nerve endings damaged or stimulated. They play an important role in triggering and regulating inflammatory response. Thus, they are important mediums between the nervous system and immune system. Recent studies have revealed that neuropeptides secreted by ocular surface nerves are considered to be an important factor involved in the pathogenesis of DE. Therefore, this paper summarized the research progress on the roles of neuropeptides underlying the mechanisms of the pathogenesis of DE, analyzed the latest points of view and research hot spots, so as to provide references for the prevention and treatment of DE.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.82160195); 江西省重点研发计划项目(No.20181BBG70004,20203BBG73059); 广东省梅州市人民医院科研培育项目(No.PY-C2021043, PY-C2021060)
