目的：比较不同屈光状态儿童及青少年的脉络膜参数，探讨眼球生物学参数与脉络膜参数之间的关系。

方法：横断面研究。收集就诊于合肥市第二人民医院眼科3～18岁的121例儿童及青少年眼部资料，均取右眼入组。散瞳验光测量屈光度，计算等效球镜(SER)，根据SER分为三组：正视组(-0.50结果：矫正年龄前三组患者TCA、LA、SA和CT均有差异(均P<0.001)，CVI无差异(P>0.05)。矫正年龄后三组患者TCA、LA、SA、CT和CVI均有差异(均P<0.001)，三组TCA、LA、SA、CT两两比较均有差异(均P<0.001)，均正视组中最高，中高度近视组最低。而三组CVI两两比较显示仅中高度近视组明显低于正视组(P=0.014)。多元回归分析表明，SER与LA显著相关(P=0.020)，CT是影响眼轴长度(AL)的因素(P=0.028)。

结论：较高的近视程度伴随脉络膜LA减少和CVI的下降，提示中心凹下脉络膜血流减少可能与近视进展有关。

METHODS:A cross sectional study. A total of 121 healthy children and adolescents(121 right eyes)aged 3-18 years treated in the Second People's Hospital of Hefei were collected. The data were divided into three groups according to spherical equivalent refraction(SER): emmetropia(-0.50RESULTS:TCA, LA, SA and CT were all different among the three groups before age correction(all P<0.001), and CVI was not different(P >0.05). TCA, LA, SA, CT and CVI were found to be statistically different among the three groups after age correction(all P<0.001), and there were differences in pairwise comparisons of TCA, LA, SA and CT among the three groups(all P<0.001), which were the highest in emmetropic eyes and lowest in moderate-to-high myopic eyes, However, the CVI in pairwise comparisons among the three groups showed that only the moderate-to-high myopia group was significantly lower than the emmetropic group(P=0.014). Multiple regression analysis showed that the LA was significantly associated with SER(P=0.020), whereas CT were significantly associated with the axial length(AL)(P=0.028).

CONCLUSIONS: The choroidal LA and CVI tend to decrease in children and adolescents with higher myopia, indicating that the decrease of sub-foveal choroidal blood flow may be related to the progression of myopia.