[关键词]
[摘要]
干眼是一种会严重影响患者工作与生活的多因素疾病，至今发生机制未完全明确，尚无标准动物模型。非Sjö；gren 综合征干眼作为干眼的主要类型之一，需要进一步对其进行探究。随着干眼机制研究的深入，干眼动物模型也不断发展和完善。因此本文综述了包括药物、手术、外源性损害、行为模式、饮食结构改变等在内的非Sjö；gren 综合征干眼的动物造模方法，阐释不同模型的特点，分析存在的问题，并对今后研究提出展望和思考。
[Key word]
[Abstract]
Dry eye is a multifactorial disease, which seriously affect the work and life of patients. Since the pathogenesis of dry eye has not been clarified so far, there is no standard animal model available now. Non-Sjögren syndrome dry eye is one of the main types of dry eye, which requires further research. Studies on dry eye mechanisms have led to the development and improvement of animal models. In this paper, the methods of animal models of non-Sjögren syndrome dry eye, including drug treatments, surgery, exogenous injury, behavioral patterns, changes in diet, are reviewed. In addition,different models are described, the problems are analyzed and perspectives and reflections on future research are offered.
[中图分类号]
[基金项目]
国家自然科学基金青年基金项目(No.81904302); 上海市自然科学基金项目(No.21ZR1460100); 上海市青年科技英才扬帆计划项目(No.19YF1445000); 上海市卫生健康委员会项目(No. 20214Y0116,201940130)
