[关键词]
[摘要]
自飞秒激光小切口角膜基质透镜取出术(small incision lenticule extraction，SMILE)普遍开展以来，术中取出的角膜基质透镜作为副产品已得到广泛的研究和应用，其作为一种良好的生物材料可以在一定程度上弥补角膜材料的匮乏。本文针对SMILE来源的角膜基质透镜的结构特征，各种保存方法如冷冻保存法、无水氯化钙法、甘油保存法等对其厚度、透明度、机械性能等方面的影响，及其在矫正远视和散光，治疗圆锥角膜、角膜穿孔、Mooren溃疡和翼状胬肉共存、角膜皮样瘤、准分子激光角膜原位磨镶术后角膜扩张、青光眼等眼科疾病中的相关应用进行综述，以期为深入研究及临床应用提供参考。
[Key word]
[Abstract]
Since small incision lenticule extraction(SMILE)was universally performed, intraoperative corneal stromal lenticules as a by-product of SMILE has been widely studied and applied. As a good biomaterial, it can make up for the lack of corneal material to some extent. In this review, we describe the structural features of the corneal stromal lenticules derived from SMILE, summarize the impact of various preservation methods such as freezing preservation, anhydrous calcium chloride preservation and glycerin preservation upon its thickness, transparency and mechanical properties, and discuss its related applications in treating hyperopia and astigmatism, keratoconus, corneal perforation, Mooren's ulcer coexisting with a pterygium, corneal dermoid, corneal ectasia after laser in situ keratomileusis, glaucoma and other ophthalmic diseases, so that we can provide references for in-depth study and clinical application.
[中图分类号]
[基金项目]
新疆军区总医院北京路医疗区重点扶持科研项目(No.2021jzbjl001)
